Cleavage of RNA oligonucleotides by aminoglycosides.
نویسندگان
چکیده
A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 7 1 شماره
صفحات -
تاریخ انتشار 2009